December 15, 2007

Prostate Cancer Treatment Options With High Grade PIN

Prostate Cancer Treatment Options Improve Survival Rates

As treatment options improve, the survival rates for prostate cancer also improve. This is true for all stages except distant stage (metastasized) prostate cancer (National Cancer Institute Prostate Cancer Trends).

When prostate cancer is detected at the earliest stages, patients have the greatest chance for high survival rates.

One of the best tests for early detection is a biopsy for PIN or prostatic intraepithelial neoplasia. PIN is generally considered the first detectable form of precancerous cells in the prostate, and can lead to adenocarcinoma. This test is independent from a PSA screening of the blood.

The PIN biopsy removes cells from different areas of the prostate and examines them for areas of increased cells or cellular proliferation that resemble cancer, and "architectural" patterns like tufting, neuroendocrine and mucinous patterns. HGPIN spreads slowly through the prostatic ducts similar to the development of prostatic cancer.

If the biopsy results are high grade PIN or HGPIN, it is considered one of the most reliable predictors of prostate cancer at this time.

What Are The Prostate Cancer Treatment Options With High Grade PIN?

Most researchers recommend follow-up biopsies at three to six month intervals for several years, then every year for life. Additional treatment is based on gathering information about the patient's individual risk. Many therapies are being tested, including preventive androgen therapy. Most invasive therapies like surgery and radiation are not considered unless there are rapid changes in the PIN biopsies.

Early detection of prostate cancer has the added advantage of opening the door for chemoprevention as one prostate cancer treatment option. Chemoprevention involves changes in the patient's lifestyle to avoid or postpone the progress of cancer.
One study using green tea extract found 90% prevention of prostate cancer in patients with HGPIN after one year of treatment. Drug studies have found 20-25% prevention of prostate cancer during five-year studies.

Prostate cancer is the second most common cancer in men after skin cancer. It is diagnosed in approximately 220,000 new patients and kills almost 30,000 each year in the United States alone. African-American men have the highest rate of prostate cancer in the world, running 60% higher than other American men (American Cancer Society, SEER National Cancer Institute).

Prostate cancer has been detected in men as young as 20 years old and by age 80 at least 80% of men have this cancer. Because it can take decades to proliferate, considering chemoprevention as part of a patient's prostate cancer treatment options offers more pro-active and positive pathways to health.

Men should consult with their primary health care provider for their best prostate cancer treatment options and early detection procedures.

You can find more information on green tea and drug studies on prostate cancer prevention at
Sharon Jones has over 40 years training and experience in science, mainstream health care, and alternative health care. Her website is

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